My Dog Oliver had TPLO surgery on both his back legs at the same time about 4 years ago and I have to say the only supplement that I have him on is GlycanAid HA Factor and he is doing amazing. I recently had him on a diet to lose 15 pounds and now at 7 1/2 years old he is just like a puppy. I know between the weight loss and the GlycanAid he is doing the best that he can and I would recommend this product to anyone who is struggling with an dog with joint pain. I laugh every morning when Oliver moves his kibble out of the way to get to the GlycanAid tablets, always eats them first.