2 TPLO surgeries on a 100 pound American Bulldog (poor thing blew both back legs within one day of each other), this was when she was 1 year old, She’s been on the GlycanAid HA for about 4 years now and the one time we tried a different product (yes…to save $) she began limping. Zero signs of fatigue or limping on your product. It really does work. Thanks!